Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature

Pawendtaoré Esdras Zongo; Tarik Chekrine; Asmaa El Kebir; Mouna Bourhafour; Zineb Bouchbika; Nadia Benchakroun; Hassan Jouhadi; Mehdi Karkouri; Abdelhakim Lakhdar; Abdelatif Benider; Souha Sahraoui; Nezha Tawfiq

doi:doi:10.11648/j.ijn.20220602.12

Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature

Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, Nadia Benchakroun, Hassan Jouhadi, Mehdi Karkouri, Abdelhakim Lakhdar, Abdelatif Benider, Souha Sahraoui, Nezha Tawfiq

Published in International Journal of Neurosurgery (Volume 6, Issue 2)

Received: 18 July 2022 Accepted: 4 August 2022 Published: 10 August 2022

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Abstract

Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.

Published in	International Journal of Neurosurgery (Volume 6, Issue 2)
DOI	10.11648/j.ijn.20220602.12
Page(s)	38-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Metastasis, Brain, Ovary, Adenocarcinoma, Cancer

References

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[3]	Pogge von Strandmann E, Reinartz S, Wager U, Müller R. Tumor–Host Cell Interactions in Ovarian Cancer: Pathways to Therapy Failure. Trends in Cancer. Feb 2017; 3 (2): 137-48.
[4]	Thomakos N, Diakosavvas M, Machairiotis N, Fasoulakis Z, Zarogoulidis P, Rodolakis A. Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature. Cancers (Basel). 24 Jul 2019; 11 (8): 1044.
[5]	Marchetti C, Ferrandina G, Cormio G, Gambino A, Cecere S, Lorusso D, et al. Brain metastases in patients with EOC: Clinico-pathological and prognostic factors. A multicentric retrospective analysis from the MITO group (MITO 19). Gynecologic Oncology. Dec 2016; 143 (3): 532-8.
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[13]	Wohl A, Kimchi G, Korach J, Perri T, Zach L, Zibly Z, et al. Brain Metastases from Ovarian Carcinoma: An Evaluation of Prognostic Factors and Treatment. Neurol India. dDec 2019; 67 (6): 1431-6.
[14]	Celejewska A, Tukiendorf A, Miszczyk L, Składowski K, Wydmański J, Trela-Janus K. Stereotactic radiotherapy in epithelial ovarian cancer brain metastases patients. J Ovarian Res. 15 août 2014; 7: 79.
[15]	Cooper KG, Kitchener HC, Parkin DE. Cerebral Metastases from Epithelial Ovarian Carcinoma Treated with Carboplatin. Gynecologic Oncology. Nov 1994; 55 (2): 318-23.
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APA Style

Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, et al. (2022). Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. International Journal of Neurosurgery, 6(2), 38-43. https://doi.org/10.11648/j.ijn.20220602.12

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ACS Style

Pawendtaoré Esdras Zongo; Tarik Chekrine; Asmaa El Kebir; Mouna Bourhafour; Zineb Bouchbika, et al. Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. Int. J. Neurosurg. 2022, 6(2), 38-43. doi: 10.11648/j.ijn.20220602.12

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AMA Style

Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, et al. Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. Int J Neurosurg. 2022;6(2):38-43. doi: 10.11648/j.ijn.20220602.12

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@article{10.11648/j.ijn.20220602.12,
  author = {Pawendtaoré Esdras Zongo and Tarik Chekrine and Asmaa El Kebir and Mouna Bourhafour and Zineb Bouchbika and Nadia Benchakroun and Hassan Jouhadi and Mehdi Karkouri and Abdelhakim Lakhdar and Abdelatif Benider and Souha Sahraoui and Nezha Tawfiq},
  title = {Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature},
  journal = {International Journal of Neurosurgery},
  volume = {6},
  number = {2},
  pages = {38-43},
  doi = {10.11648/j.ijn.20220602.12},
  url = {https://doi.org/10.11648/j.ijn.20220602.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220602.12},
  abstract = {Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.},
 year = {2022}
}

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TY  - JOUR
T1  - Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature
AU  - Pawendtaoré Esdras Zongo
AU  - Tarik Chekrine
AU  - Asmaa El Kebir
AU  - Mouna Bourhafour
AU  - Zineb Bouchbika
AU  - Nadia Benchakroun
AU  - Hassan Jouhadi
AU  - Mehdi Karkouri
AU  - Abdelhakim Lakhdar
AU  - Abdelatif Benider
AU  - Souha Sahraoui
AU  - Nezha Tawfiq
Y1  - 2022/08/10
PY  - 2022
N1  - https://doi.org/10.11648/j.ijn.20220602.12
DO  - 10.11648/j.ijn.20220602.12
T2  - International Journal of Neurosurgery
JF  - International Journal of Neurosurgery
JO  - International Journal of Neurosurgery
SP  - 38
EP  - 43
PB  - Science Publishing Group
SN  - 2640-1959
UR  - https://doi.org/10.11648/j.ijn.20220602.12
AB  - Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.
VL  - 6
IS  - 2
ER  -

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Author Information

Pawendtaoré Esdras Zongo

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Tarik Chekrine

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Asmaa El Kebir

Department of Pathology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Mouna Bourhafour

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Zineb Bouchbika

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Nadia Benchakroun

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Hassan Jouhadi

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Mehdi Karkouri

Department of Pathology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Abdelhakim Lakhdar

Department of Neurosurgery, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Abdelatif Benider

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Souha Sahraoui

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Nezha Tawfiq

Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

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APA Style

Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, et al. (2022). Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. International Journal of Neurosurgery, 6(2), 38-43. https://doi.org/10.11648/j.ijn.20220602.12

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ACS Style

Pawendtaoré Esdras Zongo; Tarik Chekrine; Asmaa El Kebir; Mouna Bourhafour; Zineb Bouchbika, et al. Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. Int. J. Neurosurg. 2022, 6(2), 38-43. doi: 10.11648/j.ijn.20220602.12

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AMA Style

Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, et al. Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. Int J Neurosurg. 2022;6(2):38-43. doi: 10.11648/j.ijn.20220602.12

Copy | Download

@article{10.11648/j.ijn.20220602.12,
  author = {Pawendtaoré Esdras Zongo and Tarik Chekrine and Asmaa El Kebir and Mouna Bourhafour and Zineb Bouchbika and Nadia Benchakroun and Hassan Jouhadi and Mehdi Karkouri and Abdelhakim Lakhdar and Abdelatif Benider and Souha Sahraoui and Nezha Tawfiq},
  title = {Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature},
  journal = {International Journal of Neurosurgery},
  volume = {6},
  number = {2},
  pages = {38-43},
  doi = {10.11648/j.ijn.20220602.12},
  url = {https://doi.org/10.11648/j.ijn.20220602.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220602.12},
  abstract = {Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.},
 year = {2022}
}

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TY  - JOUR
T1  - Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature
AU  - Pawendtaoré Esdras Zongo
AU  - Tarik Chekrine
AU  - Asmaa El Kebir
AU  - Mouna Bourhafour
AU  - Zineb Bouchbika
AU  - Nadia Benchakroun
AU  - Hassan Jouhadi
AU  - Mehdi Karkouri
AU  - Abdelhakim Lakhdar
AU  - Abdelatif Benider
AU  - Souha Sahraoui
AU  - Nezha Tawfiq
Y1  - 2022/08/10
PY  - 2022
N1  - https://doi.org/10.11648/j.ijn.20220602.12
DO  - 10.11648/j.ijn.20220602.12
T2  - International Journal of Neurosurgery
JF  - International Journal of Neurosurgery
JO  - International Journal of Neurosurgery
SP  - 38
EP  - 43
PB  - Science Publishing Group
SN  - 2640-1959
UR  - https://doi.org/10.11648/j.ijn.20220602.12
AB  - Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.
VL  - 6
IS  - 2
ER  -

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